A new analysis of satellite data indicates the missing Malaysia Airlines plane crashed into a remote corner of the Indian Ocean, Malaysian Prime Minister Najib Razak said Monday.

The news is a major breakthrough in the unprecedented two-week struggle to find out what happened to Flight 370, which disappeared shortly after takeoff from Kuala Lumpur to Beijing with 239 passengers and crew aboard on March 8.

Dressed in a black suit, Najib announced the news in a brief statement to reporters late Monday night, saying the information was based on an unprecedented analysis of satellite data from Inmarsat.

He said the data indicated the plane flew “to a remote location, far from any possible landing sites.”

“It is therefore with deep sadness and regret that I must inform you that, according to this new data, Flight MH370 ended in the southern Indian Ocean.”

He said Malaysia Airlines has informed the families of passengers of the plane's fate.

Selamat Omar, the father of a 29-year-old aviation engineer who was on the flight, said some members of families of other passengers broke down in tears at the news.

“We accept the news of the tragedy. It is fate,” Selamat told The Associated Press in Kuala Lumpur.

Selamat said the airline hasn't told the families yet whether they will be taken to Australia, which is coordinating the search for the plane. He said they expect more details Tuesday.

A multinational force has searched a wide swath of Asia trying to find the plane. (AP)