New York Yankees star Alex Rodriguez was suspended through 2014 and All-Stars Nelson Cruz, Jhonny Peralta and Everth Cabrera were banned 50 games apiece Monday when Major League Baseball disciplined 13 players in a drug case _ the most sweeping punishment since the Black Sox scandal nearly a century ago.

Ryan Braun's 65-game suspension last month and previous penalties bring to 18 the total number of players sanctioned for their relationship to Biogenesis of America, a closed anti-aging clinic in Florida accused of distributing banned performing-enhancing drugs.

The harshest penalty was reserved for Rodriguez, the New York Yankees slugger, a three-time Most Valuable Player and baseball's highest-paid star. He said he would appeal his suspension, which covers 211 games, by Thursday's deadline. And since arbitrator Fredric Horowitz isn't expected to rule until November or December, Rodriguez is free to play the rest of this season.

The other 12 players have already agreed to their 50-game penalties.

MLB said A-Rod's drug penalty was for “his use and possession of numerous forms of prohibited performance-enhancing substances, including testosterone and human growth hormone over the course of multiple years.”

His punishment under the labor contract was “for attempting to cover up his violations of the program by engaging in a course of conduct intended to obstruct and frustrate the office of the commissioner's investigation.”

Rodriguez admitted four years ago that he used performance-enhancing drugs while with Texas from 2001-03, but has repeatedly denied using them since.

Sidelined since hip surgery in January, Rodriguez was due to make his season debut for the Yankees five hours after the suspension, in a series opener at the Chicago White Sox.

“I am disappointed with the penalty and intend to appeal and fight this through the process. I am eager to get back on the field and be with my teammates in Chicago tonight,” Rodriguez said in Chicago. He arrived at U.S. Cellular Field in a dark Cadillac, wearing a dark suit. A-Rod waved at fans about 100 feet away behind barricades, and went into a side entrance.

The suspensions are thought to be the most at once for off-the-field conduct since 1921, when Commissioner Kenesaw Mountain Landis banned eight Chicago White Sox players for life for throwing the 1919 World Series against Cincinnati: Shoeless Joe Jackson, Eddie Cicotte, Happy Felsh, Chick Gandil, Fred McMullen, Charles “Swede” Risberg, Buck Weaver and Claude “Lefty” Williams. They had been suspended by the team the previous year and were penalized by baseball even though they had been acquitted of criminal charges.

As for the modern-day All-Stars, Cruz, an outfielder, leads Texas in RBIs and Peralta has been a top hitter and slick-fielding shortstop for Detroit, a pair of teams in the midst of pennant races. They will be eligible to return for the postseason.

Others agreeing included Yankees catcher Francisco Cervelli and outfielder Fernando Martinez; Philadelphia pitcher Antonio Bastardo; Seattle catcher Jesus Montero; New York Mets infielder Jordany Valdespin and outfielder Cesar Puello; Houston pitcher Sergio Escalona; and free agent pitchers Fautino De Los Santos and Jordan Norberto.

While the players' association has fought many drug penalties over the past three decades, attitudes of its membership have shifted sharply in recent years and union staff encouraged settlements in the Biogenesis probe.

“The accepted suspensions announced today are consistent with the punishments set forth in the Joint Drug Agreement, and were arrived at only after hours of intense negotiations between the bargaining parties, the players and their representatives,” union head Michael Weiner said. “For the player appealing, Alex Rodriguez, we agree with his decision to fight his suspension. We believe that the Commissioner has not acted appropriately ... The union, consistent with its history, will defend his rights vigorously.

“The union's members have made it clear that they want a clean game,” he added. “They support efforts to discipline players, and harshly, to help ensure an even playing field for all.”

A-Rod intimated Friday that New York did not want him to return; Yankees answered Monday with a prepared statement:

“We are compelled to address certain reckless and false allegations concerning the Yankees' role in this matter,” the team said. “The New York Yankees in no way instituted and/or assisted MLB in the direction of this investigation; or used the investigation as an attempt to avoid its responsibilities under a player contract; or did its medical staff fail to provide the appropriate standard of care to Alex Rodriguez.”

Baseball's drug agreement says the appeal hearing shall start no later than 20 days after the filing of the grievance and the arbitrator is charged with making a decision 25 days after the hearing starts. However, the schedule can be altered by agreement of management and the union. Weiner says a settlement is possible but not likely.

Players have often succeeded at persuading arbitrators to overturn or shorten drug suspensions. In the era before the drug agreement, LaMarr Hoyt, Ferguson Jenkins, Pascual Perez and Willie Wilson were among those who had success in hearings, and Steve Howe's lifetime ban for a seventh suspension related to drugs or alcohol was cut to 119 days.

Cruz, eligible to return to Texas for the postseason if the Rangers make the playoffs, attributed his action to a gastrointestinal infection, helicobacter pylori, and said he had lost 40 pounds following the 2011 season.

“I made an error in judgment that I deeply regret, and I accept full responsibility for that error,” he said in a statement. “I should have handled the situation differently, and my illness was no excuse.”

Peralta can rejoin Detroit for a season-ending three-game series at Miami _ not far from the former office of Biogenesis.

In a statement released by the Tigers, Peralta said in “spring of 2012, I made a terrible mistake that I deeply regret.” Peralta apologized to his teammates and “the great fans in Detroit,” saying he knows he let “many good people down.”

MLB's investigation began last year after San Francisco outfielder and All-Star game MVP Melky Cabrera tested positive for elevated testosterone, as did Oakland pitcher Bartolo Colon and San Diego catcher Yasmani Grandal. The probe escalated in January when the Miami New Times published documents obtained from former Biogenesis associate Porter Fisher that linked several players to Biogenesis.

MLB said Melky Cabrera, Colon and Grandal will not receive additional discipline and it found no violations for Washington pitcher Gio Gonzalez and Baltimore infielder Danny Valencia, both linked to Biogenesis in media reports.

In June, baseball struck a deal for Biogenesis founder Tony Bosch to cooperate. After holding investigatory interviews with the players, MLB presented evidence to the players' union along with its intended penalties, starting the final round of negotiations.

“Those players who have violated the program have created scrutiny for the vast majority of our players, who play the game the right way,” baseball Commissioner Bud Selig said. “We continue to attack this issue on every front _ from science and research, to education and awareness, to fact-finding and investigative skills.” (AP)