CLEVELAND (AP) ― Chris Sale won his first career start, limiting Cleveland to one run in 6 2/3 innings and leading the Chicago White Sox to a 4-2 win over the Indians on Monday night.

Sale pitched out of Chicago’s bullpen the past two seasons but moved into the rotation after ace Mark Buehrle left as a free agent this winter. The left-hander, who had made 79 relief appearances, took a one-hit shutout into the sixth. In his longest outing, Sale allowed three hits and struck out five.

The 23-year-old had little trouble with a Cleveland team that came in batting .153.

Rookie Hector Santiago gave up Jose Lopez’s leadoff homer in the ninth before getting his second save.

A.J. Pierzynski hit a two-run homer in the first, four batters after Alejandro De Aza homered leading off against Josh Tomlin (0-1).

Indians manager Manny Acta rested some of his left-handed regulars after a long season-opening series with Toronto and because of how tough Sale can be on lefties.

It didn’t do much good.

Sale handled Cleveland’s right-handed hitters, too.

When the White Sox selected Sale in the first round in 2010, the team’s immediate need was for a reliever and he had been reliable in that role. But Buehrle’s departure left open a spot in the rotation and the White Sox decided to convert Sale. If his first start is any indication, he seems to be in the right spot.

Sale coasted into the seventh before giving up a leadoff single to Shelley Duncan. He came back and got Jason Kipnis to hit into a double play, but manager Robin Ventura, who said before the game that Sale was not on a strict pitch count, decided 100 was enough and pulled his young lefty.

Offense bails out Yu Darvish

ARLINGTON, Texas (AP) ― Yu Darvish overcame a rocky start and got a big boost from the powerful Texas lineup, winning his much-anticipated major league debut in the Rangers’ 11-5 victory over the Seattle Mariners on Monday night.

After giving up four runs while throwing 42 pitches in the first inning, then allowing another run in the second, Darvish (1-0) settled down and later retired 10 in a row while pitching into the sixth.

Nelson Cruz hit a three-run homer in the third for Texas to tie the game at 5, then Mitch Moreland and Josh Hamilton both went deep in the fourth to give Darvish an 8-5 lead. Ian Kinsler added a three-run blast in the eighth.

Darvish was Japan’s top pitcher before the Rangers committed more than $107 million to acquire him, including his guaranteed $56 million, six-year contract.

Miami 6, Philadelphia 2

LA Angels 5, Minnesota 1

San Francisco 7, Colorado 0

Milwaukee 7, Chicago 5

NY Yankees 6, Baltimore 2

Boston 4, Toronto 2

St. Louis 7, Cincinnati 1

NY Mets 4, Washington 3

Houston 8, Atlanta 3

Oakland 1, Kansas City 0